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Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
Published on: July 17, 2020
Highly Exo-Selective Epoxidation and Hydroxylation of Triquinacene and Its Derivatives: all-exo-Hexahydroxytriquinane
Rainer Haag1, Richard Zuber, Sylvie Donon
1Institut für Organische Chemie and Institut für Anorganische Chemie,Georg-August-Universität Göttingen, Tammannstrasse 2-4, D-37077 Göttingen, Germany.
Abstract:
Epoxidation of triquinacene 3 with dimethyldioxirane proceeded with a high degree of exo-face selectivity to give a quantitative yield of a 1:1.5 mixture of all-exo-4a and endo,exo,exo-triepoxytriquinane 4b. Subsequent lithium aluminum hydride reduction of the all-exo-triepoxide 4a gave all-exo-2,5,8-5a and all-exo-2,5,9-trihydroxytriquinane 5b, respectively. The straightforward 3-fold dihydroxylation of triquinacene 3 led exclusively to the all-exo-hexahydroxytriquinane 8 in one step. X-ray crystal structure analyses confirmed the configuration of the triepoxide 4b and the hexaacetate 9 of the hexol 8.
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