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Adverse events in peripheral progenitor cell collection: a 7-year experience
1Institute for Transfusion Medicine, University Clinics Essen, Germany. rainer.moog@uni-essen.de
Journal of Hematotherapy & Stem Cell Research
|October 24, 2001
Summary
Peripheral progenitor cell (PPC) collection is generally safe, but adverse events occur. Most patient-related side effects, like paresthesias from citrate toxicity, are manageable with calcium supplementation.
Area of Science:
- Hematology
- Transfusion Medicine
- Medical Device Technology
Background:
- Peripheral progenitor cell (PPC) collection via apheresis is a common procedure.
- Limited data exists on the frequency and nature of adverse events during PPC harvesting.
Purpose of the Study:
- To retrospectively analyze adverse events associated with PPC collection.
- To identify the incidence and types of complications in apheresis procedures.
Main Methods:
- Retrospective analysis of 540 PPC collections over 7 years.
- Categorization of adverse events into collection-associated technical issues and patient/donor-related side effects.
Main Results:
- Patient/donor-related side effects occurred in 19.8% of collections, primarily paresthesias due to citrate toxicity, managed with calcium.
- Venous access issues (blood flow alarms, return line blockades) affected 11.3% and 4.3% respectively.
- Technical problems with apheresis machines occurred in 11.7% of collections; 10 collections were discontinued due to adverse events.
Conclusions:
- PPC collection has a notable rate of adverse events, with patient-related issues (paresthesias) being most common and treatable.
- Venous access problems and technical device malfunctions are significant concerns requiring attention.
- While generally safe, apheresis procedures necessitate vigilance for potential complications and timely management.