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Preparation and Use of HIV-1 Infected Primary CD4+ T-Cells as Target Cells in Natural Killer Cell Cytotoxic Assays
12:07

Preparation and Use of HIV-1 Infected Primary CD4+ T-Cells as Target Cells in Natural Killer Cell Cytotoxic Assays

Published on: March 14, 2011

HIV-1 actively replicates in naive CD4(+) T cells residing within human lymphoid tissues

D A Eckstein1, M L Penn, Y D Korin

  • 1Gladstone Institute of Virology and Immunology, School of Medicine, University of California, San Francisco, San Francisco, CA 94141, USA.

Immunity
|October 24, 2001
PubMed
Summary

Human lymphoid tissues enable de novo infection of resting naive T cells by HIV-1. These quiescent cells productively replicate the virus, contributing to viral load and potential elimination.

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