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Related Experiment Videos

Meloxicam inhibits rabbit ovulation.

A S Salhab1, M N Gharaibeh, M S Shomaf

  • 1Department of Pharmacology, University of Jordan, Amman, Jordan. Assalhab@ju.edu.jo

Contraception
|October 24, 2001
PubMed
Summary
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Meloxicam, a selective cyclo-oxygenase-2 (COX-2) inhibitor, significantly inhibits rabbit ovulation in a dose- and time-dependent manner. Further research is needed to explore COX-2 inhibitors as nonhormonal contraceptives.

Area of Science:

  • Reproductive Biology
  • Pharmacology

Background:

  • Selective cyclo-oxygenase-2 (COX-2) inhibitors are nonsteroidal anti-inflammatory drugs.
  • Ovulation is a critical process in mammalian reproduction.

Purpose of the Study:

  • To investigate the effects of meloxicam, a selective COX-2 inhibitor, on ovulation in rabbits.
  • To determine the dose- and time-dependency of meloxicam's effect on ovulation.

Main Methods:

  • Adult female Californian rabbits were administered varying doses of meloxicam intraperitoneally at different time points postcoitus.
  • Rabbits were assessed for ovulation, implantation, and pregnancy on Day 10 of gestation.
  • Ovarian tissues and hormonal levels were analyzed.

Main Results:

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  • Meloxicam significantly inhibited ovulation in a dose- and time-dependent manner.
  • Complete ovulation inhibition was observed with 20 mg/kg meloxicam at 2 and 5 hours postcoitus.
  • Lower doses and later administration times showed reduced or no inhibition of ovulation or implantation.

Conclusions:

  • Meloxicam effectively inhibits ovulation in rabbits.
  • The study suggests potential for selective COX-2 inhibitors as nonhormonal contraceptive agents, warranting further investigation.