Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sudden cardiac death.

R Virmani1, A P Burke, A Farb

  • 1Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA. virmani@afip.osd.mil

Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology
|October 24, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multiple arterial injuries and prolonged cholesterol feeding do not increase percent lumen stenosis: impact of compensatory enlargement in the microswine model.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2015
Same author

Reperfusion injury in the ischemic myocardium.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2015
Same author

The pathology of murine coxsackievirus B3 myocarditis: An in situ hybridization study.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2015
Same author

Pathologic features of aortitis.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2015
Same author

Subvalvular left ventricular outflow tract obstruction caused by "rhinonodular" calcification.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2015
Same author

Pulmonary mycobacterial spindle cell pseudotumor in a lung transplant patient: progression without therapy and response to therapy.

Transplant infectious disease : an official journal of the Transplantation Society·2015
Same journal

Green Heart: Methylene Blue administration in a hemodynamically unstable infant following cardiac arrest due to parental co-sleeping.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2026
Same journal

Adventitial Melanocytosis ("Blue nevus") of the Aorta.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2026
Same journal

Lipomatous Hamartoma of the Semilunar Valve Exhibits Molecular Genetic Characteristics of Lipoma.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2026
Same journal

Proteomic profiling of whole tissue sections in cardiac ATTR amyloidosis reveals increased extracellular matrix remodeling.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2026
Same journal

A large-scale plasma proteomic study reveals the preclinical evolution and potential biomarkers for coronary atherosclerosis.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2026
Same journal

Burden of cardiovascular disease in victims of fatal intoxication: An autopsy study.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2026
See all related articles

Sudden cardiac death causes vary by age, with coronary anomalies and thrombosis being key factors in younger adults. Understanding plaque rupture versus erosion is crucial for preventing these fatal events.

Area of Science:

  • Cardiology
  • Pathology
  • Forensic Medicine

Background:

  • Sudden cardiac death (SCD) accounts for approximately 50% of cardiac deaths, with causes varying significantly by age.
  • In younger individuals, coronary anomalies and cardiomyopathies are common, while adults often present with coronary atherosclerosis.

Purpose of the Study:

  • This review focuses on the coronary artery causes of SCD, particularly congenital anomalies and coronary thrombosis.
  • It aims to elucidate the pathological mechanisms and risk factors associated with these conditions.

Main Methods:

  • Review of autopsy studies and morphologic analyses of victims of sudden coronary death.
  • Examination of pathological substrates, including coronary artery anomalies and atherosclerotic plaque characteristics.

Related Experiment Videos

Main Results:

  • Congenital coronary artery anomalies, such as the left coronary artery arising from the right sinus of Valsalva, are frequently lethal in adults under 35.
  • Coronary thrombosis causes about 60% of sudden coronary deaths, with plaque rupture being the most common mechanism, linked to lipid abnormalities.
  • Plaque erosion, seen in younger individuals, differs pathologically and lacks association with lipid abnormalities.

Conclusions:

  • Congenital coronary anomalies and coronary thrombosis are significant contributors to sudden cardiac death, especially in younger populations.
  • The distinct pathological features and risk factor profiles of plaque rupture and erosion highlight the complexity of atherosclerotic disease progression and thrombosis.