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Ciprofloxacin: in vivo genotoxicity studies
B A Herbold1, S Y Brendler-Schwaab, H J Ahr
1Bayer AG, PH-PD Toxikologie, Gentoxikologie, Gebäude 514, Postfach 101709, D-42096 Wuppertal, Germany. bernd.herbold.bh@bayer-ag.de
Mutation Research
|October 24, 2001
Summary
Ciprofloxacin, an antibiotic, showed no genotoxic effects in vivo despite in vitro findings. Long-term studies confirmed ciprofloxacin is non-carcinogenic, supporting its safety for therapeutic use.
Area of Science:
- Pharmacology and Toxicology
- Genetics and Molecular Biology
Background:
- Ciprofloxacin is a widely used fluoroquinolone antibiotic.
- In vitro studies indicated potential genotoxicity due to inhibition of eukaryotic topoisomerase-II at high concentrations.
Purpose of the Study:
- To evaluate the in vivo genotoxic relevance of ciprofloxacin.
- To assess the safety of ciprofloxacin for therapeutic use.
Main Methods:
- In vivo genotoxicity testing including micronucleus test, chromosome analysis, dominant lethal assay, and unscheduled DNA synthesis (UDS) tests.
- Comparison with existing in vitro and in vivo data.
- Rodent long-term bioassays for carcinogenicity assessment.
Main Results:
- No genotoxic effects were observed in any of the in vivo test systems.
- Ciprofloxacin demonstrated a lack of carcinogenicity in long-term rodent studies.
Conclusions:
- In vivo studies indicate that ciprofloxacin does not pose a genotoxic risk.
- The findings support the established safety profile of ciprofloxacin for antimicrobial therapy.
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