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An automated technique for measuring hippocampal volumes from MR imaging studies
K M Gosche1, J A Mortimer, C D Smith
1Institute on Aging, University of South Florida, Tampa 33612-3899, USA.
AJNR. American Journal of Neuroradiology
|October 24, 2001
Abstract:
We describe an automated volumetric measure of the hippocampus obtained with software called the Knowledge-Guided MRI Analysis Program (KGMAP). Postmortem MR images from 56 participants in the Nun Study were used to validate the measure. KGMAP-determined volumes strongly correlated with those obtained with manual tracings and neurofibrillary pathologic findings of Alzheimer disease in the hippocampus. KGMAP provides a rapid and accurate estimate of hippocampal volume that is suitable for use in clinical practice.