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Related Experiment Videos

Sleep-disordered breathing and hypotension.

C Guilleminault1, J L Faul, R Stoohs

  • 1Stanford University Sleep Disorders Center, Stanford University, Stanford, California 94403, USA. cguil@leland.stanford.edu

American Journal of Respiratory and Critical Care Medicine
|October 24, 2001
PubMed
Summary
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Low blood pressure (BP) is common in upper airway resistance syndrome (UARS), affecting nearly one-fifth of patients. This study highlights the link between UARS, low BP, and orthostatic intolerance (OI), suggesting further testing for OI in UARS patients.

Area of Science:

  • Cardiology
  • Sleep Medicine
  • Physiology

Background:

  • Low blood pressure (BP) is an underrecognized condition.
  • Upper airway resistance syndrome (UARS) is a sleep-related breathing disorder.
  • Orthostatic intolerance (OI) is characterized by symptoms upon standing due to BP regulation issues.

Purpose of the Study:

  • To investigate the prevalence of low BP in patients undergoing polysomnography.
  • To explore the association between low BP, UARS, and OI.
  • To assess BP regulation in UARS patients with OI using tilt-table testing.

Main Methods:

  • Retrospective analysis of 4,409 subjects for low BP prevalence.
  • Polysomnography and tilt-table testing on selected patient groups (UARS with OI, normotensive UARS, insomnia with low BP, OSAS, controls).

Related Experiment Videos

  • 24-hour ambulatory BP monitoring in UARS with OI and healthy controls.

    • Main Results:

    • Low BP was found in 2.3% of subjects, significantly higher in UARS (23%) than OSAS (0.06%).
    • Subjects with UARS and OI exhibited lower mean daytime BP and a greater systolic BP drop during tilt-table testing compared to controls.
    • Tilt-table testing revealed impaired BP homeostasis in UARS patients with OI.

    Conclusions:

    • Low BP and OI are prevalent in a significant portion of UARS patients.
    • Tilt-table testing is a valuable tool for diagnosing OI in UARS.
    • Further research into the mechanisms linking UARS, low BP, and OI is warranted.