Related Experiment Video
Updated: Aug 2, 2026
09:56
In Vivo Multimodal Imaging and Analysis of Mouse Laser-Induced Choroidal Neovascularization Model
Published on: January 21, 2018
Preretinal neovascularisation associated with choroidal melanoma.
1Department of Ophthalmology, Northwestern University Medical School, 645 N Michigan Avenue Suite 440, Chicago, IL 60611, USA.
The British Journal of Ophthalmology
|October 24, 2001
Summary
Preretinal neovascularisation (NVE) is a rare complication of choroidal melanoma. This study reports three cases, suggesting potential causes and treatment options like scatter photocoagulation for NVE.
Area of Science:
- Ophthalmology
- Oncology
- Medical Research
Background:
- Choroidal melanoma can rarely cause iris or choroidal neovascularization.
- Preretinal neovascularization (NVE) from the retinal circulation is an even rarer complication of choroidal melanoma.
Observation:
- Three cases of choroidal melanoma with overlying NVE were identified.
- Patients presented with choroidal melanomas, serous retinal detachment, and NVE.
- Two cases exhibited retinal capillary non-perfusion, one with retinal telangiectasis.
Findings:
- One patient's NVE persisted post-radiotherapy, causing vitreous hemorrhage, but regressed with scatter photocoagulation.
- Two patients underwent enucleation; one received pre-enucleation radiotherapy.
- Histological examination confirmed preretinal vessels in one case.
Implications:
- NVE in choroidal melanoma may stem from tumor angiogenic factors, inflammation, retinal detachment, vascular occlusion, or radiation.
- The optimal management for NVE associated with choroidal melanoma requires further investigation.
- Localized scatter photocoagulation may be a beneficial treatment modality for NVE in select cases.
