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First Total Synthesis of an Exceptionally Potent Antitumor Saponin, OSW-1
Shaojiang Deng1, Biao Yu, Yun Lou
1State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, China.
The Journal of Organic Chemistry
|October 25, 2001
Abstract:
OSW-1 (1), an acylated disaccharide cholestane saponin from Ornithogalum saudersiae with exceptionally potent antitumor activity, was first synthesized from commercially available dehydroisoandrosterone, L-arabinose, and D-xylose in total 27 steps with the longest linear sequence of 14 steps and in 6% yield.
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