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Human pulmonary adiospiromycosis
Abstract:
Emmonsia crescens, a fungus that causes granulomatous pulmonary adiospiromycosis, is an uncommon human pathogen. Histopathologic and ultrastructural evaluation of a new case of human adiospiromycosis from Guatemaia showed pulmonary granulomatosis in respose to the inhaled spores of the fungus. The wall of each spore consisted of three zones. A fenestrated layer was clearly demonstrated within the middle zone. Neither budding nor endosporulation was detected. Our findings support the pathogenetic view that E crescens produces local changes by progressive enlargement of the inhaled spores and surrounding granulomas. Characteristically, the fungus does not propagate or disseminate within the lung
Insights
Emmonsia crescens causes adiaspiromycosis, a lung disease. This study shows the fungus enlarges inhaled spores, forming granulomas, but does not spread within the lungs.
Area of Science:
- Mycology
- Pathology
- Pulmonology
Background:
- Emmonsia crescens is an uncommon fungal pathogen.
- Adiaspiromycosis is a granulomatous lung disease caused by E. crescens.
Purpose of the Study:
- To histopathologically and ultrastructurally evaluate a case of human adiaspiromycosis.
- To understand the pathogenetic mechanisms of E. crescens in pulmonary infections.
Main Methods:
- Histopathologic examination of lung tissue.
- Ultrastructural analysis of fungal spores.
Main Results:
- Pulmonary granulomatosis was observed in response to inhaled E. crescens spores.
- Spore walls have three zones, with a fenestrated middle layer.
- No budding or endosporulation was detected.
- E. crescens causes local changes via spore enlargement and granuloma formation.
Conclusions:
- The findings support the progressive enlargement of inhaled spores and surrounding granulomas as the primary pathogenetic mechanism.
- E. crescens does not propagate or disseminate within the lung.