Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Vascular Spasm01:16

Vascular Spasm

The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last for...
Arteries of the Upper Limbs01:12

Arteries of the Upper Limbs

The subclavian artery transitions into the axillary artery as it exits the chest and enters the axillary region. This artery is critical for supplying blood to the shoulder area, including the head of the humerus, through the humeral circumflex arteries. As the vessel continues into the upper arm or brachium, it becomes the brachial artery. This artery plays a key role in vascularizing the brachial region and bifurcates at the elbow into several branches. These branches include the deep...
Arteries of Lower Limbs01:20

Arteries of Lower Limbs

The external iliac artery transitions out of the body cavity, entering the femoral region of the lower leg, and is renamed the femoral artery at the point where it traverses the body wall. This artery is responsible for the distribution of blood to the thigh's deep muscles and the skin's ventral and lateral regions, achieved through several minor branches and the lateral deep femoral artery, which also spawns a lateral circumflex artery. The knee area receives blood from the genicular artery,...
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Peripheral Artery Disease IV: Nursing Management01:26

Peripheral Artery Disease IV: Nursing Management

The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses, temperature changes,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Aortic Curvature Instead of Angulation Allows Improved Estimation of the True Aorto-iliac Trajectory.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2015
Same author

Endovascular repair or surveillance of patients with small AAA.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2005
Same author

Primary endovascular repair of juxtarenal aneurysms with fenestrated endovascular grafting.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2004
Same author

Current outcomes in endovascular repair of abdominal aortic aneurysms.

The Journal of cardiovascular surgery·2003
Same author

Leadership challenges for carotid disease in the 21st century.

Cardiovascular surgery (London, England)·2003
Same author

The use of glycoprotein IIb/IIIa antagonists in peripheral arterial occlusion.

Techniques in vascular and interventional radiology·2002
Same journal

Assisted dying and the silencing of medicine's next generation.

Lancet (London, England)·2026
Same journal

Linguistic pragmatism: a woman with progressive abdominal pain in Thailand.

Lancet (London, England)·2026
Same journal

Medical compartmentalisation: a patient with chromosome 22q11.2 deletion syndrome in Japan.

Lancet (London, England)·2026
Same journal

[<sup>177</sup>Lu]Lu-edotreotide versus everolimus for gastroenteropancreatic neuroendocrine tumours (COMPETE): a phase 3, multicentre, randomised, open-label, superiority trial.

Lancet (London, England)·2026
Same journal

Research priorities for characterising Bundibugyo virus.

Lancet (London, England)·2026
Same journal

Rethinking treatment sequence in advanced gastroenteropancreatic neuroendocrine tumours.

Lancet (London, England)·2026
See all related articles

Related Experiment Video

Updated: Jun 25, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Peripheral arterial disease.

K Ouriel1

  • 1Department of Vascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA. ouurielk@ccf.org

Lancet (London, England)
|October 25, 2001
PubMed
Summary
This summary is machine-generated.

Peripheral arterial disease (PAD) management focuses on treating atherosclerosis and risk factors. Critical limb ischemia requires interventions like angioplasty or surgery based on lesion anatomy.

More Related Videos

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research
08:42

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

Published on: October 22, 2014

A Rabbit Venous Interposition Model Mimicking Revascularization Surgery using Vein Grafts to Assess Intimal Hyperplasia under Arterial Blood Pressure
07:02

A Rabbit Venous Interposition Model Mimicking Revascularization Surgery using Vein Grafts to Assess Intimal Hyperplasia under Arterial Blood Pressure

Published on: May 15, 2020

Related Experiment Videos

Last Updated: Jun 25, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research
08:42

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

Published on: October 22, 2014

A Rabbit Venous Interposition Model Mimicking Revascularization Surgery using Vein Grafts to Assess Intimal Hyperplasia under Arterial Blood Pressure
07:02

A Rabbit Venous Interposition Model Mimicking Revascularization Surgery using Vein Grafts to Assess Intimal Hyperplasia under Arterial Blood Pressure

Published on: May 15, 2020

Area of Science:

  • Vascular Medicine
  • Cardiovascular Surgery

Background:

  • Lower extremity peripheral arterial disease (PAD) commonly causes intermittent claudication, manageable with lifestyle changes and medication.
  • Systemic atherosclerosis poses a greater mortality risk than limb loss in many PAD patients.
  • Critical limb ischemia (CLI), marked by rest pain, ulceration, or gangrene, significantly elevates limb-loss risk.

Purpose of the Study:

  • To outline the management strategies for peripheral arterial disease (PAD).
  • To differentiate treatment approaches for intermittent claudication versus critical limb ischemia (CLI).
  • To guide intervention selection for CLI based on lesion characteristics.

Main Methods:

  • Review of current therapeutic guidelines for PAD.
  • Analysis of risk factors and outcomes in PAD patients.
  • Evaluation of anatomical considerations for endovascular and surgical revascularization in CLI.

Main Results:

  • General atherosclerotic risk factor management is primary for PAD.
  • Limb salvage interventions are reserved for CLI.
  • Percutaneous interventions suit focal lesions; surgical revascularization is preferred for longer lesions.

Conclusions:

  • PAD management requires a dual approach: systemic risk reduction and limb-specific treatment for CLI.
  • Intervention choice for CLI is dictated by lesion length and anatomy.
  • Optimizing outcomes in CLI necessitates tailored revascularization strategies.