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Related Experiment Videos

Megestrol-induced Cushing syndrome.

G C Caparrós1, J L Zambrana, M Delgado-Fernandez

  • 1Servicio de Medicina Interna, Hospital de Poniente, El Ejido, Almería, Spain. gracia@telebase.es

The Annals of Pharmacotherapy
|October 26, 2001
PubMed
Summary
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High-dose megestrol acetate can cause Cushing syndrome in patients with renal insufficiency. This case highlights the importance of monitoring for this adverse effect, especially in vulnerable populations.

Area of Science:

  • Endocrinology
  • Nephrology
  • Pharmacology

Background:

  • Megestrol acetate, used for cachexia, possesses glucocorticoid activity.
  • Glucocorticoid effects can lead to Cushing syndrome.

Observation:

  • A 17-year-old male with unilateral renal agenesis and renal insufficiency received high-dose megestrol acetate for an eating disorder.
  • Cushing syndrome developed two months after initiating therapy.

Findings:

  • The patient presented with clinical and analytical evidence of Cushing syndrome.
  • Renal function worsened concurrently with the development of Cushing syndrome.

Implications:

  • Clinicians should consider megestrol acetate-induced Cushing syndrome in patients with renal insufficiency.

Related Experiment Videos

  • High-dose megestrol acetate poses a risk for adverse glucocorticoid effects, particularly in impaired renal function.