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Related Experiment Videos

Seizures with intravenous codeine phosphate.

M Zolezzi1, S A Al Mohaimeed

  • 1Department of Pharmaceutical Services, Riyadh Armed Forces Hospital, Kingdom of Saudi Arabia. monizolezzi@yahoo.com

The Annals of Pharmacotherapy
|October 26, 2001
PubMed
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Intravenous codeine phosphate can cause seizures in children with sickle cell anemia. Clear guidelines for its administration are needed to prevent adverse reactions during acute pain management.

Area of Science:

  • Pediatric Hematology
  • Clinical Pharmacology
  • Neurology

Background:

  • Sickle cell anemia patients often require potent analgesics for pain crises.
  • Intravenous codeine phosphate is used for acute pain management.

Observation:

  • A seven-year-old boy with sickle cell anemia experienced a tonic-clonic seizure immediately after receiving intravenous codeine phosphate for pain.
  • The seizure was successfully treated with intravenous diazepam and naloxone.

Findings:

  • Codeine phosphate-induced seizures are a rare but serious adverse effect.
  • The intravenous administration route may increase the risk of seizures, particularly in vulnerable populations like children with sickle cell anemia.

Implications:

Related Experiment Videos

  • This case highlights the need for cautious use of intravenous codeine phosphate in children with sickle cell anemia.
  • Development of specific guidelines for parenteral codeine administration is crucial to ensure patient safety and prevent seizures.