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Related Experiment Videos

Sympathetic sudomotor function and amyotrophic lateral sclerosis.

M Santos-Bento1, M de Carvalho, T Evangelista

  • 1Department of Neurology, Hospital de São José, Lisbon, Portugal.

Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders : Official Publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases
|October 26, 2001
PubMed
Summary

Amyotrophic lateral sclerosis (ALS) patients show mild, subclinical sweat function changes in weak limbs, not significant widespread hypofunction. This study evaluated sympathetic sudomotor function using the sweat imprint test in ALS.

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Area of Science:

  • Neurology
  • Neuroscience
  • Autonomic Function Testing

Background:

  • Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease primarily affecting motor neurons.
  • Autonomic nervous system involvement is not a primary feature of ALS, but dysfunction has been observed in advanced cases.
  • Sympathetic sudomotor function in ALS requires further investigation.

Purpose of the Study:

  • To evaluate sympathetic sudomotor function in patients with amyotrophic lateral sclerosis (ALS).
  • To utilize the sweat imprint test for assessing autonomic dysfunction in ALS.
  • To determine if sudomotor function is impaired in ALS patients.

Main Methods:

  • A cohort of 24 ALS patients and 25 age- and sex-matched controls were recruited.

Related Experiment Videos

  • Sweat imprint tests were performed on hands and feet of both ALS patients and controls.
  • Quantitative analysis of sweat drop counts per cm² was conducted.

    • Main Results:

    • No significant differences in sweat production were found between ALS patients and controls overall.
    • Six ALS patients exhibited lower sweat counts on hands compared to feet, a pattern not seen in controls.
    • Mild abnormalities in sweat production were identified in a subset of ALS patients, particularly in weaker limbs.

    Conclusions:

    • Significant sudomotor hypofunction is not a characteristic of amyotrophic lateral sclerosis (ALS).
    • Subclinical sudomotor changes may occur in ALS, potentially linked to limb weakness and disuse.
    • The sweat imprint test can reveal subtle autonomic alterations in specific patient groups.