Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[alpha-Fetoprotein (biology)].

G I Abelev

    Vestnik Rossiiskoi Akademii Meditsinskikh Nauk
    |October 26, 2001
    PubMed
    Summary
    This summary is machine-generated.

    Alpha-fetoprotein (AFP) reexpression in liver tumors is linked to cell-environment interactions. Disturbances in cell-extracellular matrix (ECM) interactions during tumor progression may cause AFP reappearance.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    On the path to understanding the nature of cancer.

    Biochemistry. Biokhimiia·2008
    Same author

    [The purification of the protein alternative to alfa-fetoprotein].

    Vestnik Rossiiskoi akademii meditsinskikh nauk·2007
    Same author

    [Differentiation antigens of hemoblastoses and epithelial tumors: relations to the mechanisms of transformation and progression].

    Ontogenez·2006
    Same author

    New approaches for the detection and characterization of alpha-fetoprotein epitope variants.

    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine·2003
    Same author

    [Differentiation antigens in tumors: dependence on carcinogenesis mechanisms and progression (a hypothesis)].

    Molekuliarnaia biologiia·2003
    Same author

    Epitope mapping of human alpha-fetoprotein.

    Biochemistry. Biokhimiia·2001

    Area of Science:

    • Biochemistry
    • Cell Biology
    • Oncology

    Context:

    • Alpha-fetoprotein (AFP) is a major protein in embryonic serum, synthesized by the yolk sac and fetal liver.
    • AFP synthesis significantly decreases in adult liver but reemerges in hepatomas and regenerating liver.
    • Understanding AFP regulation provides insights into liver cancer development.

    Purpose:

    • To provide a historical overview of alpha-fetoprotein (AFP) regulation.
    • To analyze the experimental basis for AFP reexpression in malignant tumors and regenerating liver.
    • To investigate the role of cell-environment interactions in AFP regulation.

    Summary:

    • AFP reexpression in liver cancer and regenerating liver is linked to hepatocyte differentiation status.
    • Hepatocyte position within the liver plate and interaction with the extracellular matrix (ECM) control AFP synthesis.

    Related Experiment Videos

  • Isolation of hepatocytes or defective ECM interactions lead to AFP reexpression, suggesting a loss of differentiation.

    • Impact:

    • Identifies disruption of cell-ECM interactions as a key factor in AFP reappearance in liver tumors.
    • Suggests that cell-environment cues are critical for maintaining differentiated liver cell function and suppressing oncofetal protein expression.
    • Provides a potential mechanism for understanding tumor dedifferentiation and biomarker reexpression in hepatocellular carcinoma.