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Related Experiment Videos

Hypothalamic digoxin and irritable bowel syndrome.

A R Kumar1, P A Kurup

  • 1Department of Biochemistry, University of Kerala, Trivandrum.

Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology
|October 26, 2001
PubMed
Summary
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Hypothalamic digoxin, a membrane Na+-K+ ATPase inhibitor, is implicated in irritable bowel syndrome (IBS) pathogenesis. This study links elevated digoxin and right hemispheric dominance to IBS development.

Area of Science:

  • Neuroendocrinology
  • Gastroenterology
  • Biochemistry

Background:

  • The hypothalamus produces endogenous digoxin, a membrane Na+-K+ ATPase inhibitor.
  • Digoxin influences neurotransmitter transport, hemispheric dominance, and glycoconjugate synthesis.
  • Alterations in digoxin metabolism may contribute to irritable bowel syndrome (IBS) development.

Purpose of the Study:

  • To investigate digoxin levels in patients with IBS.
  • To explore the correlation between digoxin status and hemispheric dominance in IBS.

Main Methods:

  • Assessed isoprenoid pathway, tryptophan/tyrosine catabolism, and glycoconjugate metabolism in IBS patients.
  • Compared biochemical markers and hemispheric dominance in IBS patients versus controls.

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Main Results:

  • Upregulated isoprenoid pathway, increased HMG CoA reductase activity, serum digoxin, and dolichol levels in IBS.
  • Reduced RBC membrane Na+-K+ ATPase activity, serum magnesium, and ubiquinone in IBS patients.
  • Increased tryptophan catabolites, reduced tyrosine catabolites, elevated glycosaminoglycans, and increased glycosaminoglycan-degrading enzymes were observed, correlating with right hemispheric dominance.

Conclusions:

  • Hypothalamic digoxin and right hemispheric dominance may play a role in the etiology of IBS.
  • Biochemical alterations in IBS suggest a link to neuroendocrine and metabolic dysregulation.