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Related Experiment Videos

CD4(+) regulatory T cells.

S Read1, F Powrie

  • 1Sir William Dunn School of Pathology, University of Oxford, South Parks Road, OX1 3RE, Oxford, UK. simon.read@path.ox.ac.uk

Current Opinion in Immunology
|October 26, 2001
PubMed
Summary
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Regulatory T cells, a type of CD4(+) T cell, are crucial for controlling immune responses and preventing immune pathology. Their generation in the thymus and periphery, and identification in humans, opens avenues for studying immune-mediated diseases.

Area of Science:

  • Immunology
  • Cellular Biology

Background:

  • CD4(+) T cells play a critical role in regulating immune responses.
  • Immune pathology can be controlled by specialized T cells that suppress immune activity.

Purpose of the Study:

  • To summarize recent findings on the generation and identification of CD4(+) regulatory T cells.
  • To highlight the significance of these cells in understanding immune-mediated diseases.

Main Methods:

  • Review of recent scientific reports and literature.
  • Identification of CD4(+) regulatory T cells in various biological compartments.

Main Results:

  • Compelling evidence supports the role of CD4(+) T cells in immune suppression.
  • CD4(+) regulatory T cells are generated in both the thymus and periphery.

Related Experiment Videos

  • These regulatory cells have been identified in human subjects.

    • Conclusions:

    • CD4(+) regulatory T cells are key players in controlling immune pathology.
    • The identification of these cells in humans facilitates further research into immune-mediated diseases.