Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pattern ERG and psychophysical functions in Best's disease.

M Jarc-Vidmar1, P Popović, M Hawlina

  • 1University Eye Clinic, Medical Center Ljubljana, Slovenia. Martina.Jarc-Vidmar@mf.uni-lj.si

Documenta Ophthalmologica. Advances in Ophthalmology
|October 27, 2001
PubMed
Summary

Pattern ERG (electroretinography) effectively tracks Best

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The spectrum of clinical presentation in haploinsufficiency of A20; a case report of a novel mutation in <i>TNFAIP3</i> gene.

Frontiers in pediatrics·2023
Same author

CB<sub>2</sub> receptor activation causes an ERK1/2-dependent inflammatory response in human RPE cells.

Scientific reports·2017
Same author

Electroretinography and optical coherence tomography reveal abnormal post-photoreceptoral activity and altered retinal lamination in patients with enhanced S-cone syndrome.

Documenta ophthalmologica. Advances in ophthalmology·2015
Same author

Genetic risk for co-occurrence of type 1 diabetes and celiac disease is modified by HLA-C and killer immunoglobulin-like receptors.

Tissue antigens·2014
Same author

Percutaneous radiofrequency ablation of small renal cell carcinoma: technique, complications, and outcomes.

Journal of B.U.ON. : official journal of the Balkan Union of Oncology·2013
Same author

Percutaneous imaging-guided radiofrequency ablation of small renal cell carcinoma: techniques and outcomes of 24 treatment sessions in 18 consecutive patients.

Journal of B.U.ON. : official journal of the Balkan Union of Oncology·2011

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Genetics

Background:

  • Best's disease is an inherited macular dystrophy characterized by progressive visual impairment.
  • Electrophysiological tests like EOG and ERG are used to assess retinal function.
  • The role of pattern ERG (PERG) in monitoring disease progression is not fully understood.

Purpose of the Study:

  • To evaluate neurosensory retinal function in patients with Best's disease using PERG.
  • To correlate PERG responses with visual acuity, disease stage, and visual field loss.
  • To compare PERG findings with EOG and full-field flash ERG (ffERG) results.

Main Methods:

  • 12 patients (24 eyes) with varying stages of Best's disease were studied.
  • Pattern ERG (PERG), full-field flash ERG (ffERG), and electrooculography (EOG) were performed.
  • Visual acuity and visual field defects were assessed and correlated with electrophysiological data.

Main Results:

  • All patients exhibited abnormal EOG responses and normal ffERG responses.
  • PERG responses (P50 and N95 amplitudes) were normal in early stages with good visual acuity.
  • Reduced PERG amplitudes correlated with decreased visual acuity and progressive central visual field loss.

Conclusions:

  • Pattern ERG (PERG) demonstrates progressive abnormalities in Best's disease, reflecting neurosensory retinal changes.
  • PERG is a valuable tool for electrophysiologically determining disease progression, unlike EOG and ffERG.
  • PERG indicates relative preservation of retinal function in the initial stages of Best's disease.

Related Experiment Videos