Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Naproxen absorption in children.

B M Ansell, D B Hanna, M Stoppard

    Current Medical Research and Opinion
    |January 1, 1975
    PubMed
    Summary

    Naproxen suspension is safe and effective for children with rheumatic disorders. Pharmacokinetic studies show similar blood levels and half-life to adults, supporting a twice-daily dosage for effective treatment.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The associations of CD4 count, CD4/CD8 ratio, and HIV viral load with survival from non-small cell lung cancer in persons living with HIV.

    AIDS care·2021
    Same author

    Subclinical cardiovascular disease in HIV controller and long-term nonprogressor populations.

    HIV medicine·2019
    Same author

    Still's Disease Followed into Adult Life.

    Proceedings of the Royal Society of Medicine·2010
    Same author

    AIDS-defining opportunistic illnesses in the HAART era in New York City.

    AIDS care·2007
    Same author

    Meta-analysis: upper gastrointestinal tolerability of valdecoxib, a cyclooxygenase-2-specific inhibitor, compared with nonspecific nonsteroidal anti-inflammatory drugs among patients with osteoarthritis and rheumatoid arthritis.

    Alimentary pharmacology & therapeutics·2005
    Same author

    Presurgical intravenous parecoxib sodium and follow-up oral valdecoxib for pain management after laparoscopic cholecystectomy surgery reduces opioid requirements and opioid-related adverse effects.

    Acta anaesthesiologica Scandinavica·2004

    Area of Science:

    • Pediatric Rheumatology
    • Pharmacokinetics
    • Drug Safety

    Background:

    • Rheumatic disorders affect children, requiring effective pain management.
    • Naproxen is a common nonsteroidal anti-inflammatory drug (NSAID) used for rheumatic conditions.
    • Pediatric dosing and pharmacokinetics for naproxen suspension require specific investigation.

    Purpose of the Study:

    • To evaluate the pharmacokinetic profile of naproxen in children.
    • To determine peak plasma levels and plasma curves of naproxen in pediatric patients.
    • To assess the suitability of naproxen suspension for treating rheumatic disorders in children.

    Main Methods:

    • A single oral dose of naproxen suspension was administered to 9 children (mean age 10.8 years) with rheumatic disorders.
    • Peak plasma levels and plasma curves of naproxen were measured.
    • Data were analyzed to compare pediatric pharmacokinetics with adult data.

    Main Results:

    • Naproxen exhibited no significant difference in peak blood levels and half-life between children and adults.
    • The naproxen suspension formulation was well-tolerated in the pediatric participants.
    • No adverse effects were observed during the study.

    Conclusions:

    • A twice-daily dosage regimen of naproxen, similar to adults, is likely suitable for children.
    • Naproxen suspension demonstrates favorable safety and pharmacokinetic profiles in pediatric patients with rheumatic disorders.
    • This study supports the therapeutic use of naproxen suspension in pediatric rheumatology.

    Related Experiment Videos