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Absolute configuration of trixanolides from Trixis pallida
C Kotowicz1, L R Hernández, C M Cerda-García-Rojas
1Instituto de Química Orgánica, Facultad de Bioquímica, Química y Farmacia, Universidad Nacional de Tucumán, Ayacucho 471, S.M. de Tucumán 4000, Argentina.
Journal of Natural Products
|October 27, 2001
Abstract:
The aerial parts of Trixis pallida afforded seven known trixanolides (18-24) together with 17 new trixanolides (1-17). Their structures were determined by 1D and 2D NMR techniques, while the absolute configuration of the trixane skeleton was determined using the Mosher method and turned out to be enantiomeric to that reported using the Horeau method. This result is further discussed from the biosynthetic point of view.