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Single-pass continuous flow peritoneal dialysis using two catheters.

C Cruz1, A Melendez, F A Gotch

  • 1Fresenius Neomedica, Chicago, Illinois 60611, USA.

Seminars in Dialysis
|October 27, 2001
PubMed
Summary
This summary is machine-generated.

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Continuous flow peritoneal dialysis (CFPD) using two catheters showed high clearance rates for urea and creatinine. This study suggests CFPD may be a promising dialysis modality for patients with access failure.

Area of Science:

  • Nephrology
  • Renal Replacement Therapy

Background:

  • Renewed interest in continuous flow peritoneal dialysis (CFPD).
  • Standard practice involves a second catheter for access failure, enabling acute CFPD studies.
  • Limited data exists on CFPD efficacy in patients with temporary dual-catheter access.

Purpose of the Study:

  • To evaluate the efficacy of continuous flow peritoneal dialysis (CFPD) in patients temporarily utilizing two catheters due to access failure.
  • To determine key performance metrics of CFPD, including clearance and ultrafiltration rates.
  • To establish a foundation for the future development of CFPD as a dialysis modality.

Main Methods:

  • Four patients undergoing temporary dual-catheter access for peritoneal dialysis were studied.
  • A standardized CFPD protocol was employed using 1.5% dextrose solution, 2 L fill, 200 ml/min inflow, and proportionate outflow for 4 hours.

Related Experiment Videos

  • Effective peritoneal clearance (Kpe) for urea (KpeU) and creatinine (KpeCr), ultrafiltration rate (Qf), and mass transfer coefficient (MTC) for urea were measured.

    • Main Results:

    • Mean effective peritoneal clearance for urea (KpeU) was 40 ml/min and for creatinine (KpeCr) was 28 ml/min.
    • Mean ultrafiltration rate (Qf) was 13.4 ml/min.
    • Mean mass transfer coefficient (MTC) for urea was 40 ml/min, consistent with kinetic modeling and historical data.

    Conclusions:

    • The achieved Kpe, MTC, and Qf were significantly higher than reported by other investigators.
    • The enhanced performance may be attributed to the use of two separate catheters, promoting adequate dialysate mixing.
    • These findings support the potential of CFPD as an effective dialysis modality, particularly in managing access failure.