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Dynamics of SEN virus infection among injection drug users

L E Wilson1, T Umemura, J Astemborski

  • 1Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, MD 21231-1001, USA. lwilsond@jhmi.edu

The Journal of Infectious Diseases
|October 27, 2001
PubMed

Insights

Hepatitis viruses SEN virus-D (SENV-D) and SEN virus-H (SENV-H) are common in injection drug users. Long-term follow-up reveals frequent reinfection and viral persistence, but clinical significance remains unclear.

Area of Science:

  • Hepatology
  • Virology
  • Infectious Diseases

Background:

  • Hepatitis viruses SEN virus-D (SENV-D) and SEN virus-H (SENV-H) are DNA viruses associated with post-transfusion hepatitis.
  • Injection drug users (IDUs) are a population at risk for viral infections.

Purpose of the Study:

  • To investigate the prevalence, persistence, and reinfection rates of SENV-D and SENV-H in injection drug users (IDUs).

Main Methods:

  • Polymerase chain reaction (PCR) was used to detect SENV-D and SENV-H DNA in serum samples from 397 IDUs in Baltimore.
  • Longitudinal follow-up was conducted on a subset of IDUs to assess viral persistence and reinfection over a median of 9.3 years.

Main Results:

  • SENV-D infection was detected in 32.7% and SENV-H in 37.5% of IDUs.
  • After a median of 9.3 years, SENV-D persisted in 61.0% and SENV-H in 26.9% of initially infected individuals.
  • High rates of reinfection were observed for both SENV-D (77.8%) and SENV-H (55.6%).

Conclusions:

  • SENV-D and SENV-H infections are prevalent and dynamic in Baltimore IDUs, characterized by viral clearance, persistence, and frequent reinfection.
  • The long-term clinical impact of SENV infections in this population requires further investigation.

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