Thermodynamic considerations of the interaction between caffeine and paracetamol in aqueous solutions

Caffeine interacts physically with paracetamol thus producing changes in some physicochemical properties of paracetamol. There is evidence that the interaction may be in the form of a 1:1 association complex. Complexation of caffeine and paracetamol leads to increases in the aqueous solubility of the later. Thermodynamic influences play significant roles in the stabilization of the formed complex.