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[Angiogenesis and macrophage infiltration in Borrmann type IV gastric cancer]
J Koga1, Y Kakeji, Y Sumiyoshi
1Department of Surgery and Science (Surgery II), Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582.
Fukuoka Igaku Zasshi = Hukuoka Acta Medica
|October 30, 2001
Abstract:
The clinical significance of angiogenesis was investigated in Borrmann type IV gastric cancer. Tumors with high microvessel density (MVD) often metastasized to the liver and lymph nodes. A significant correlation was recognized between macrophage infiltration and MVD. However, MVD was not a prognostic factor. Peritoneal dissemination was a prognostic factor in Borrmann type IV gastric cancer. Thus, angiogenesis plays an important role in the metastasis, but not prognosis in Borrmann type IV gastric cancer.