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[Counteraction effect of intermittent -Gx on changes of responsiveness of basilar artery in tail-suspended rats]
Objective:
To investigate counteracting effects of intermittent -Gx exposure on changes of responsiveness of basilar artery in tall-suspended rats.
Method:
Rats tail-suspended for 3 wk were daily subjected to 1 h 1.5 G or 2.6 G centrifugation, simulating -Gx exposure of various G values. Responses of perfused isolated basilar arterial rings to KCl was examined.
Result:
Maximal isometric contractile response to KCl were significantly enhanced in arterial rings isolated from 3 wk tail-suspended rats as compared with that from simultaneous control rats (P < 0. 05). However, maximal isometric contractile responses to KCl of arterial rings isolated from 3 wk tail-suspended plus daily -Gx exposure rats were no difference as compared with that from simultaneous control rats, and were significantly decreased (P < 0.05) as compared with that from 3 wk tail-suspended rats.
Conclusion:
Daily intermittent -Gx exposure as a countermeasure to prevent the effects of simulated weightless on changes in responsiveness of basilar artery from tail-suspended rats was valid.
