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Related Experiment Videos

Backward masking task performance in stable, euthymic out-patients with bipolar disorder.

G M MacQueen1, L T Young, T M Galway

  • 1Mood Disorders Program, McMaster University, Hamilton, Ontario, Canada.

Psychological Medicine
|October 30, 2001
PubMed
Summary

Patients with bipolar disorder show visual backward masking (VBM) impairments, with greater illness burden correlating to slower reaction times. Treatment status did not impact VBM task performance in this study.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Psychology

Background:

  • Visual backward masking (VBM) impairment is suggested in bipolar disorder.
  • Clinical features contributing to VBM impairment are not well-described.

Purpose of the Study:

  • Assess VBM impairment in euthymic bipolar disorder patients.
  • Identify clinical correlates of VBM impairment.

Main Methods:

  • 28 euthymic bipolar disorder patients and 28 controls completed two VBM tasks.
  • Tasks involved target stimulus location and identification.
  • Reaction times and error rates were measured across varying inter-stimulus intervals.

Main Results:

  • Bipolar disorder patients were significantly slower and made more errors on VBM tasks.

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  • Reaction times correlated with past illness burden, especially depression history.
  • Treatment status, including lithium use, did not affect performance.

    • Conclusions:

    • Neuropsychological deficits, including VBM impairment, are confirmed in euthymic bipolar disorder.
    • VBM tasks may link clinical variables like illness burden to neural pathways.
    • Further research can elucidate pathophysiology of cognitive deficits in bipolar disorder.