Related Experiment Videos
Catalytic, asymmetric synthesis of siphonarienal
M A Calter1, W Liao, J A Struss
1Department of Chemistry, University of Rochester, Rochester, New York 14627-0216, USA. Calter@chem.rochester.edu
The Journal of Organic Chemistry
|October 30, 2001
Abstract:
This paper describes the synthesis of the marine natural product, siphonarienal. The key step of this synthesis is an aldol reaction that constructs most of the skeleton and sets all three stereocenters of the target in one step from commercially available starting materials. Deoxygenation and chain homologation steps complete the synthesis.