Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Palatal development in Twirler mice.

S G Gong1, R L Eulenberg

  • 1Department of Orthodontics and Pediatric Dentistry, University of Michigan, 1011 North University Avenue, Ann Arbor, MI 48109-1078, USA. sggong@umich.edu

The Cleft Palate-Craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association
|October 30, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Anti-EJ antibody positive antisynthetase syndrome with pulmonary hypertention:a case report].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases·2025
Same author

Canada's First National Oral Health Research Strategy (2024-2030).

Journal of dental research·2024
Same author

Development of a model to investigate the effects of prolonged ischaemia on the muscles of mastication of male Sprague Dawley rats.

Archives of oral biology·2022
Same author

[Peripheral small airway dysfunction differences between idiopathic pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases·2018
Same author

[Clinical and imaging features of pulmonary veno-occlusive disease and pulmonary capillary hemangioma].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases·2018
Same author

[Clinical analysis of Behçet disease associated with pulmonary vascular disease].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases·2017
Same journal

Life-Course Patterns of Medical and Dental Care in Patients with Cleft Lip and/or Palate: A Nationwide Claims-Based Study.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association·2026
Same journal

Asymmetry of Maxillary Bone Structure in Unilateral Cleft Lip and Palate: A Cone Beam Computed Tomography Study.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association·2026
Same journal

Global and Regional Perspectives on Parental Satisfaction in Cleft Lip Care: A Scoping Review.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association·2026
Same journal

Assessment of Felt Needs of Caregivers of Children With Orofacial Cleft in a Low-Middle-Income Country: A Longitudinal Study.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association·2026
Same journal

Bridging Ergonomic Awareness and Practice in Cleft Surgery: Insights From An International Craniofacial Cleft Workshop.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association·2026
Same journal

Patient-Specific 3D Printed Palatal Protection Plates for Le Fort III Osteotomy in Syndromic Midface Hypoplasia: What We Do.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association·2026
See all related articles

Twirler (Tw) mice exhibit growth-retarded secondary palatal shelves and a wider midface, leading to cleft palates in all homozygous mutants. These findings in mice mirror human cleft palate development.

Area of Science:

  • Developmental biology
  • Craniofacial development
  • Genetics

Background:

  • Cleft palate is a common birth defect with complex etiology.
  • Murine models are crucial for understanding human craniofacial development and malformations.

Purpose of the Study:

  • To characterize secondary palate development in Twirler (Tw) mice.
  • To quantitatively evaluate craniofacial dimensions in homozygous Tw embryos.

Main Methods:

  • Histological analysis of secondary palatal shelf development.
  • Quantitative assessment of midface width and palatal shelf length in coronal sections.

Main Results:

  • Homozygous Tw embryos displayed significantly retarded growth of secondary palatal shelves.

Related Experiment Videos

  • The timing of palatal shelf elevation was delayed in Tw/Tw embryos.
  • A significantly wider midface was observed in homozygous Tw embryos compared to wild-type littermates.

    • Conclusions:

    • The combination of shortened palatal shelves and a widened midface in Tw/Tw mice directly results in secondary palate clefting.
    • Findings in the Twirler mouse model provide insights into the mechanisms underlying human cleft palate.
    • This study reinforces the utility of murine models for investigating craniofacial anomalies.