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Suppression of mouse killing and apomorphine-induced social aggression in rats by local anesthesia of the mystacial

D H Thor, W B Ghiselli

    Journal of Comparative and Physiological Psychology
    |January 1, 1975
    PubMed
    Summary

    Local anesthesia using lidocaine significantly reduced aggression in rats, including mouse-killing and fighting behaviors. This suggests sensory input is crucial for initiating and maintaining aggressive responses.

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    Area of Science:

    • Neuroscience
    • Behavioral Science
    • Pharmacology

    Background:

    • Aggression is a complex behavior influenced by sensory input.
    • Local anesthetics like lidocaine can alter sensory processing.
    • Previous studies indicated lidocaine reduces shock-elicited fighting in rats.

    Purpose of the Study:

    • To investigate the effect of lidocaine on mouse-killing behavior.
    • To examine lidocaine's impact on spontaneous, drug-induced social aggression in rats.

    Main Methods:

    • Bilateral lidocaine or placebo injections were administered to known mouse-killing rats.
    • Attack and kill latencies were recorded.
    • Rats exhibiting intense apomorphine-induced fighting were tested with lidocaine anesthesia.

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    Main Results:

    • Lidocaine significantly increased attack and kill latencies in mouse-killing rats.
    • A third of rats failed to kill after initial lidocaine administration.
    • Lidocaine markedly reduced apomorphine-induced conspecific fighting.

    Conclusions:

    • Sensory information plays a critical role in stimulus-bound attack behaviors.
    • Local anesthesia can modulate different types of aggression, supporting distinct central aggression systems.