Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hypothalamic regulation of sleep.

R Salin-Pascual1, D Gerashchenko, M Greco

  • 1West Roxbury VA Medical Center and Harvard Medical School, 1400 VFW Parkway, West Roxbury, MA 02132, USA.

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
|October 30, 2001
PubMed
Summary

Narcolepsy, a sleep disorder, is linked to hypocretin, a neuropeptide regulating feeding and energy. A defect in hypocretin neurons may disrupt sleep, mood, appetite, and rhythms.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evidence for Longitudinally Polarized W Bosons in the Electroweak Production of Same-Sign W Boson Pairs in Association with Two Jets in pp Collisions at sqrt[s]=13  TeV with the ATLAS Detector.

Physical review letters·2025
Same author

First Measurement of the Decay Dynamics in the Semileptonic Transition of D^{+(0)} into the Axial-Vector Meson K[over ¯]_{1}(1270).

Physical review letters·2025
Same author

Observation of Three Resonant Structures in the Cross Section of e^{+}e^{-}→π^{+}π^{-}h_{c}.

Physical review letters·2025
Same author

Precision Measurement of the Branching Fraction of D^{+}→μ^{+}ν_{μ}.

Physical review letters·2025
Same author

Observation of Charmonium h_{c} Radiative Decays to Multiple Light Hadrons and the Tensor State f_{2}(1270).

Physical review letters·2025
Same author

Observation of tt[over ¯] Production in Pb+Pb Collisions at sqrt[s_{NN}]=5.02  TeV with the ATLAS Detector.

Physical review letters·2025

Area of Science:

  • Neuroscience
  • Sleep Medicine
  • Metabolic Research

Background:

  • Narcolepsy is a sleep disorder marked by short REM sleep latency.
  • A neuropeptide, hypocretin, regulates feeding and energy metabolism.
  • Recent discoveries link narcolepsy with hypocretin.

Purpose of the Study:

  • To review evidence connecting hypocretin and sleep.
  • To propose a mechanism for behavioral disruptions due to hypocretin defects.

Main Methods:

  • Review of existing studies on hypocretin and sleep.
  • Analysis of research linking lateral hypothalamus defects to hypocretin neurons.

Main Results:

  • Evidence supports a link between hypocretin and sleep regulation.

Related Experiment Videos

  • Hypocretin neuron involvement in the lateral hypothalamus is implicated.

    • Conclusions:

    • Defects in hypocretin neurons likely cause disturbances in sleep, mood, appetite, and rhythms.
    • This peptide offers a potential pathway to understand narcolepsy and related behavioral disruptions.