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Updated: Aug 8, 2026

Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies
Published on: October 6, 2022
Systemic tizanidine hydrochloride (Zanaflex) partially decreases experimental postoperative pain in rats
A H Hord1, D D Denson, M I Azevedo
1Division of Pain Medicine, Department of Anesthesiology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
Implications:
Tizanidine was given systemically to rats with experimental postoperative pain. Partial pain relief was obtained, but the effect was not clinically significant. Although systemic tizanidine is effective in relieving experimental neuropathic pain, it is not as effective for postoperative pain.
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