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Hair follicle predetermination.

A A Panteleyev1, C A Jahoda, A M Christiano

  • 1Department of Dermatology, Columbia University, College of Physicians and Surgeons, 630 W. 168th Street, Vanderbilt Clinic VC-1526, New York, NY 10032, USA. ap374@columbia.edu

Journal of Cell Science
|October 30, 2001
PubMed
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Hair follicle (HF) cycling involves predetermined cellular events. Stem cells from the bulge region form a

Area of Science:

  • Hair follicle (HF) biology
  • Dermatology
  • Stem cell research

Background:

  • Understanding hair follicle (HF) cyclic transformations requires knowledge of cellular rearrangements.
  • Molecular data on HF biology is limited without understanding cellular kinetics.

Purpose of the Study:

  • To present a novel interpretation of cellular processes during HF cycling: the hypothesis of hair follicle predetermination.
  • To propose modifications to existing HF cellular kinetics models regarding stem cell recruitment and HF dual origin.

Main Methods:

  • Compilation of existing evidence.
  • Analysis of cellular kinetics and gene expression patterns.

Main Results:

  • The ascending HF portion originates from secondary hair germ cells, not bulge stem cells.

Related Experiment Videos

  • Bulge-derived cells migrate to form the 'lateral disc' and transform into the secondary hair germ.
  • Germ cells' sensitivity to follicular papilla (FP) signaling is predetermined by the previous hair cycle.

    • Conclusions:

    • The hypothesis of hair follicle predetermination offers a new perspective on HF cycling.
    • Bulge-derived cells play a crucial role in initiating subsequent hair growth cycles.
    • Cellular commitment to HF layer production is established during the transformation of bulge-derived cells into the secondary hair germ.