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[Cyclic agranulocytosis (author's transl)].

W Schönberger, G Schönberger, H Stopfkuchen

    Klinische Padiatrie
    |March 1, 1975
    PubMed
    Summary

    Cyclic neutropenia, a condition causing recurrent low neutrophil counts, can be managed. Prophylactic tetracycline treatment effectively prevented symptoms like fever and sore throat in a pediatric patient.

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    Medizinische Klinik, Intensivmedizin und Notfallmedizin·2017

    Area of Science:

    • Pediatric Hematology
    • Immunology
    • Infectious Diseases

    Context:

    • Cyclic agranulocytosis is a rare disorder characterized by periodic severe drops in neutrophil counts.
    • This condition often presents with recurrent infections, fever, stomatitis, and sore throat.
    • Early diagnosis and intervention are crucial for managing cyclic neutropenia.

    Purpose:

    • To report a case of cyclic agranulocytosis in a pediatric patient.
    • To evaluate the efficacy of prophylactic tetracycline treatment in preventing symptomatic episodes.
    • To highlight the importance of timely intervention in managing cyclic neutropenia.

    Summary:

    • A 10.5-year-old girl experienced cyclic agranulocytosis with symptoms including stomatitis, sore throat, and fever every ~3 weeks since 6 months of age.
    • Prophylactic oral tetracycline was initiated 2 days before expected neutrophil decline.
    • The patient remained clinically asymptomatic for 7 months with this treatment regimen.

    Impact:

    • This case demonstrates that prophylactic tetracycline can effectively prevent symptomatic episodes of cyclic agranulocytosis in children.
    • Early and consistent prophylactic treatment can significantly improve the quality of life for patients with cyclic neutropenia.
    • The findings support the use of prophylactic antibiotics as a management strategy for cyclic neutropenia.

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