Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fentanyl-selective polymeric membrane electrode.

L J Peng1, M L Wen, Y Yao

  • 1Department of Chemistry, Yunnan University, Kunming, Yunnan, PR China.

Die Pharmazie
|October 31, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A nomogram for predicting heterogeneous etiology of atherosclerosis in the left anterior descending coronary artery using geometric morphological parameters.

Clinical radiology·2025
Same author

[Meta analysis of rock salt aerosol therapy for respiratory tract diseases].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases·2022
Same author

[Comparison between photodynamic therapy and interventional esophageal stent implantation in dysphagia caused by advanced esophageal cancer].

Zhonghua yi xue za zhi·2020
Same author

Identification and characterization of probiotic yeast isolated from digestive tract of ducks.

Poultry science·2018
Same author

[Downregulation of large conductance calcium-activated potassium channels in paraventricular nucleus contributes to sympathoexcitation in rats with chronic heart failure].

Zhonghua xin xue guan bing za zhi·2018
Same author

[Role of autophagy in leukemia and research progress].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi·2018
Same journal

Comparative <i>In Vitro</i> Release Profiling of Brand and Generic Metoprolol Extended-Release Formulations in the Context of Product Switching.

Die Pharmazie·2026
Same journal

The Role of SGLT2 Inhibitors in the Management of Diabetic Retinopathy: A Literature Review.

Die Pharmazie·2026
Same journal

Research Progress on Ferroptosis-Inducing Compounds in Tumor Cells.

Die Pharmazie·2026
Same journal

Mocetinostat Ameliorates Pathological Cardiac Hypertrophy via Suppression of Ferroptosis Through Nrf2 Pathway.

Die Pharmazie·2026
Same journal

Different Effects of the Anticonvulsant Drugs Phenytoin and Phenobarbital on Forskolin-Induced BeWo Syncytialization.

Die Pharmazie·2026
Same journal

MC4R Antagonists: A Promising New Hope for the Treatment of Cachexia and Wasting Diseases.

Die Pharmazie·2026
See all related articles

A new membrane electrode accurately determines fentanyl citrate in injections. This ion-pair complex method offers a reliable and sensitive approach for pharmaceutical analysis.

Area of Science:

  • Analytical Chemistry
  • Electrochemistry
  • Pharmaceutical Analysis

Background:

  • Fentanyl citrate is a potent analgesic commonly administered via injection.
  • Accurate quantification of fentanyl citrate in pharmaceutical formulations is crucial for patient safety and therapeutic efficacy.
  • Existing analytical methods may have limitations in terms of sensitivity, selectivity, or speed for routine injection analysis.

Purpose of the Study:

  • To develop and validate a novel poly (vinyl chloride) membrane electrode for the determination of fentanyl citrate in injection solutions.
  • To assess the electrode's performance characteristics, including linearity, sensitivity, and selectivity.
  • To evaluate the practical applicability of the developed electrode for real-world pharmaceutical quality control.

Main Methods:

Related Experiment Videos

  • Fabrication of a poly (vinyl chloride) membrane electrode incorporating a fentanyl-tetrakis(4-chlorophenyl)borate ion-pair complex and dibutyl phthalate plasticizer.
  • Electrochemical measurements to determine fentanyl citrate concentration.
  • Optimization of electrode parameters, including pH range and response linearity.
  • Interference studies with common inorganic ions, structural analogues, and drug additives.

Main Results:

  • The developed electrode exhibited a linear response for fentanyl citrate over a concentration range of 1 x 10(-5) to 1 x 10(-2) mol.dm-3.
  • A consistent slope of 59.3 +/- 0.6 mV/decade was observed, indicating good Nernstian behavior.
  • The electrode demonstrated a low detection limit of 8 x 10(-6) mol.dm-3 fentanyl citrate (2.7 µg cm-3 fentanyl).
  • Negligible interference was noted from various inorganic cations, structural analogues, and common injection additives.
  • Successful application of the electrode for fentanyl citrate determination in actual injection samples, with results correlating well to the United States Pharmacopoeia standard method.

Conclusions:

  • The developed poly (vinyl chloride) membrane electrode is a sensitive, selective, and reliable tool for the quantitative determination of fentanyl citrate in injections.
  • This electrochemical method offers a viable alternative to conventional techniques for pharmaceutical quality control of fentanyl citrate formulations.
  • The electrode's ease of use and good performance characteristics make it suitable for routine analysis in pharmaceutical laboratories.