Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Overcoming original (antigenic) sin.

D E Anderson1, M P Carlos, L Nguyen

  • 1School of Medicine, University of California-Davis, Davis, CA 95616, USA.

Clinical Immunology (Orlando, Fla.)
|October 31, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The persistence of seroprotective levels of antibodies after vaccination with PreHevbrio, a 3-antigen hepatitis B vaccine.

Vaccine·2023
Same author

Bone density and strength from thoracic and lumbar CT scans both predict incident vertebral fractures independently of fracture location.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2020
Same author

Mars Science Laboratory Observations of Chloride Salts in Gale Crater, Mars.

Geophysical research letters·2020
Same author

Neurophysiological evidence of impaired attention and working memory in untreated hematologic cancer patients.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2019
Same author

Prediction of incident vertebral fracture using CT-based finite element analysis.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2018
Same author

Population-based study of age- and sex-related differences in muscle density and size in thoracic and lumbar spine: the Framingham study.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2018
Same journal

A novel JAK1 mutation identified in a patient with severe atopic dermatitis phenotype: Mechanistic insights and IL-4Rα targeted therapy.

Clinical immunology (Orlando, Fla.)·2026
Same journal

VNN1 aggravates sepsis by promoting inflammation and oxidative stress through PPARγ signaling VNN1 in sepsis.

Clinical immunology (Orlando, Fla.)·2026
Same journal

Comparison between glioblastoma and brain metastases: How epigenetic remodeling can enhance immunotherapy.

Clinical immunology (Orlando, Fla.)·2026
Same journal

JAK-STAT3-MYC axis defines pathogenic stem cell-like memory CD4<sup>+</sup> T cells in rheumatoid arthritis.

Clinical immunology (Orlando, Fla.)·2026
Same journal

The baseline vaginal immune milieu is an important determinant of the inflammatory response induced by penile-vaginal sex.

Clinical immunology (Orlando, Fla.)·2026
Same journal

Adulthood diagnosis of Nijmegen breakage syndrome in twins with antibody deficiency clinical presentation.

Clinical immunology (Orlando, Fla.)·2026
See all related articles

Original antigenic sin impacts immune responses to viral variants. Immunizing with multiple peptide variants creates a broader, more durable T helper cell response, potentially overcoming this phenomenon.

Area of Science:

  • Immunology
  • Virology
  • Vaccinology

Background:

  • Original antigenic sin describes a bias in adaptive immunity where secondary responses favor the original antigen over new variants.
  • T helper cells are crucial for adaptive immunity and antibody production, suggesting they may also be subject to original antigenic sin.
  • This phenomenon is highly relevant for vaccines against rapidly mutating viruses like HIV and HCV.

Purpose of the Study:

  • To investigate if T helper cell responses exhibit original antigenic sin.
  • To compare the immunogenicity of single peptide epitopes versus peptide cocktails.
  • To explore novel vaccine strategies to circumvent original antigenic sin.

Main Methods:

  • Priming the immune system with either a single peptide epitope or a cocktail of related peptide variants.

Related Experiment Videos

  • Assessing the breadth and durability of T helper cell responses elicited by different priming strategies.

    • Main Results:

    • Immunization with a single peptide epitope resulted in a less broadly reactive and durable T helper cell response.
    • Immunization with a cocktail of related peptide variants expanded a more broadly reactive and durable T helper cell response.
    • The data suggest that T helper cell responses can be modulated by the priming antigen composition.

    Conclusions:

    • T helper cell responses may be subject to original antigenic sin.
    • Vaccine strategies employing diverse peptide variants can elicit broader and more durable T helper cell immunity.
    • This multi-peptide immunization approach offers a potential method to overcome original antigenic sin in vaccine development.