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Urinary transforming growth factor-beta1 levels correlate with bladder outlet obstruction
M Monga1, L L Gabal-Shehab, P Stein
1Division of Urology, University of California, San Diego Medical Center, San Diego, California 92103-8897, USA. mmonga@ucsd.edu
Summary
Urinary transforming growth factor-beta1 (TGF-beta1) levels correlate with bladder outlet obstruction (BOO). Higher TGF-beta1 in obstructed men suggests its potential as a non-invasive diagnostic marker for BOO.
Area of Science:
- Urology
- Biochemistry
- Medical Diagnostics
Background:
- Urinary transforming growth factor-beta1 (TGF-beta1) correlates with ureteropelvic junction obstruction and has been studied in prostate cancer.
- This study investigates the relationship between urinary TGF-beta1 and objective measures of bladder outlet obstruction (BOO).
Purpose of the Study:
- To test the hypothesis that urinary TGF-beta1 levels correlate with objective measures of bladder outlet obstruction (BOO).
Main Methods:
- Twenty-three men with lower urinary tract symptoms underwent urodynamic studies, including uroflowmetry and pressure flow studies.
- Patients were classified as obstructed or not obstructed using Abrams-Griffith nomograms.
- Urinary TGF-beta1 levels were measured using enzyme-linked immunosorbent assay (ELISA) from urine collected during catheterization.
Main Results:
- A strong correlation was found between urinary TGF-beta1 levels and the presence of obstruction (P = 0.025).
- Urinary TGF-beta1 levels were significantly higher in obstructed men (0.039 pg/mL) compared to non-obstructed men (0.029 pg/mL; P = 0.036).
Conclusions:
- Urinary TGF-beta1 levels demonstrate a correlation with objective measures of bladder outlet obstruction.
- Further research is warranted to evaluate urinary TGF-beta1 as a non-invasive diagnostic tool for BOO.