Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pairing-induced changes of orientation maps in cat visual cortex.

S Schuett1, T Bonhoeffer, M Hübener

  • 1Max-Planck-Institut für Neurobiologie, 82152, Martinsried, Germany.

Neuron
|October 31, 2001
PubMed
Summary

Timing is critical for visual cortex plasticity. Kitten visual cortex maps shift orientation preference when electrically stimulated after visual input, but not when stimulated before, validating spike time-dependent learning rules.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Christianity and fear revisited.

Journal of religion and health·2014
Same author

Chronic γ-secretase inhibition reduces amyloid plaque-associated instability of pre- and postsynaptic structures.

Molecular psychiatry·2013
Same author

[Disorders of visual perception].

Der Nervenarzt·2012
Same author

Sequence-based typing of a novel HLA-DRB1*14 allele, DRB1*1475, in a Caucasian woman.

Tissue antigens·2008
Same author

[Comparison of MultiHance and Gadovist for cerebral MR perfusion imaging in healthy volunteers].

Der Radiologe·2002
Same author

Kinase-independent requirement of EphB2 receptors in hippocampal synaptic plasticity.

Neuron·2002

Area of Science:

  • Neuroscience
  • Visual Cortex Plasticity
  • Developmental Neuroscience

Background:

  • Orientation preference maps in the visual cortex are crucial for visual processing.
  • Understanding the temporal dynamics of cortical plasticity is essential for deciphering learning mechanisms.

Purpose of the Study:

  • To investigate the precise temporal requirements for plasticity in kitten visual cortex orientation maps.
  • To determine if spike time-dependent plasticity observed in single cells applies to cortical map development.

Main Methods:

  • Pairing brief visual stimuli with electrical stimulation in the kitten visual cortex.
  • Manipulating the temporal sequence of visual and electrical activation.
  • Analyzing changes in orientation preference maps and responses to paired orientations.

Related Experiment Videos

Main Results:

  • The direction of plasticity is dependent on the relative timing of visual and electrical stimulation.
  • Cortical activation preceding electrical stimulation induced shifts in orientation preference.
  • Reversed stimulation order diminished cortical responses to the paired orientation.
  • Plasticity was less pronounced at pinwheel centers compared to their surrounds, indicating non-uniform distribution.

Conclusions:

  • Spike time-dependent learning rules are applicable at the level of cortical maps, not just single neurons.
  • Plasticity in the visual cortex is not uniform across the cortical surface.
  • Precise temporal sequencing of neural activity dictates the direction and extent of map plasticity.