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Related Experiment Videos

Conditioned taste aversion and c-Fos expression in cholestatic rats.

E S Na1, D A Fitts

  • 1Department of Psychology, University of Washington, Seattle, WA 98195-1525, USA.

Brain Research
|October 31, 2001
PubMed
Summary

Bile duct ligation in rats caused a lasting aversion to saccharin taste. While illness from the procedure increased brain activity, it did not condition a specific taste aversion response.

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Area of Science:

  • Neuroscience
  • Gastroenterology
  • Behavioral Science

Background:

  • Conditioned taste aversion (CTA) is a learned response to avoid flavors associated with illness.
  • The neural pathways underlying CTA are complex and involve brainstem nuclei.

Purpose of the Study:

  • To investigate if bile duct ligation (BDL)-induced illness can create a CTA to a saccharin taste in rats.
  • To examine the neural correlates of illness and conditioned aversion in the brainstem.

Main Methods:

  • Rats underwent bile duct ligation (BDL) and were paired with saccharin.
  • Behavioral tests (preference and taste reactivity) assessed taste aversion.
  • Immunohistochemistry was used to measure c-Fos-like immunoreactivity (FLI) in the area postrema and nucleus of the solitary tract.

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Main Results:

  • BDL rats consistently showed a conditioned taste aversion to saccharin.
  • All BDL rats, irrespective of taste pairing, exhibited increased FLI in the area postrema and nucleus of the solitary tract.
  • No evidence of conditioned FLI was observed, suggesting illness-related FLI was not specific to the taste cue.

Conclusions:

  • BDL-induced illness can establish a persistent conditioned taste aversion.
  • Increased FLI in specific brainstem areas reflects the general malaise of BDL, not a specific learned aversion.
  • The findings contribute to understanding the neural basis of illness-induced aversions.