Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Preference formation and working memory in Parkinson's disease and normal ageing.

Sylvia M L Cox1, Elka Stefanova, Ingrid S Johnsrude

  • 1Medical Research Council Cognition and Brain Sciences Unit, 15 Chaucer Road, CB2 2EF, Cambridge, UK. sylvia.cox@mrc-cbu.cam.ac.uk

Neuropsychologia
|October 31, 2001
PubMed
Summary

This study found that Parkinson's disease patients, unlike those with frontal lobe damage, did not show conditioned preferences. Familiarity effects in older adults and Parkinson's patients may obscure learning mechanisms.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characterizing functional connectivity alterations in functional/ dissociative seizures using resting-state and naturalistic fMRI.

Epilepsy & behavior : E&B·2026
Same author

Assessing cognition and quality of life in people with epilepsy: A feasibility study for mild and marked cognitive impairment.

Epilepsy & behavior : E&B·2026
Same author

Virtual Neuropsychological Assessment After Severe or Critical COVID-19: The NeuroCov Pilot Feasibility Study.

Cureus·2026
Same author

Towards the use of functional near-infrared spectroscopy as an assessment tool in disorders of consciousness.

Imaging neuroscience (Cambridge, Mass.)·2026
Same author

Prediction from Statistical Learning Aids Auditory Scene Analysis.

bioRxiv : the preprint server for biology·2026
Same author

A thalamic perspective of (un)consciousness in pharmacological and pathological states in humans.

Brain communications·2026

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Neurology

Background:

  • The amygdala and dorsal striatum are implicated in stimulus-reward and stimulus-response associations, respectively.
  • Previous human studies showed amygdala damage impairs conditioned preference learning.
  • Parkinson's disease involves dorsal striatum pathology.

Purpose of the Study:

  • To investigate conditioned preference learning in Parkinson's disease (PD) patients.
  • To compare PD patients with frontal lobe lesion patients and controls.
  • To explore the role of the dorsal striatum in conditioned preference.

Main Methods:

  • A conditioned preference task was administered to patients with Parkinson's disease, patients with frontal lobe lesions, and age-matched controls.

Related Experiment Videos

  • Working memory was assessed in all groups.
  • Preference for familiar versus novel items was evaluated.

    • Main Results:

    • Parkinson's disease patients did not exhibit conditioned preferences, similar to older controls.
    • Frontal lobe lesion patients also showed working memory deficits, but their conditioning results were not detailed.
    • Both Parkinson's disease patients and older controls showed a strong preference for familiar items, overshadowing conditioning effects.

    Conclusions:

    • The dorsal striatum may not be essential for conditioned preference learning in humans.
    • Familiarity effects significantly impact learning to like in older adults and Parkinson's patients.
    • Mechanisms of 'learning to like' show developmental progression across the lifespan.