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Related Experiment Videos

Skin pigmentation enhancers.

D A Brown1

  • 1AGI Dermatics, 205 Buffalo Avenue, Freeport, NY 11520, USA. dbrown@agiderm.com

Journal of Photochemistry and Photobiology. B, Biology
|October 31, 2001
PubMed
Summary
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Agents that enhance skin pigmentation, like dihydroxyacetone and melanins, can reduce skin cancer risk. Further research into pigmentation stimulators may offer safe photoprotection.

Area of Science:

  • Dermatology
  • Photobiology
  • Cosmetic Science

Background:

  • Endogenous skin pigmentation significantly reduces cancer risk.
  • Agents enhancing pigmentation may offer protection against photodamage and skin cancer.

Purpose of the Study:

  • To review agents that increase skin pigmentation.
  • To evaluate their efficacy and safety for photoprotection.

Main Methods:

  • Review of topical agents simulating pigmentation (dihydroxyacetone, melanins).
  • Review of agents stimulating pigmentation (e.g., PUVA, DMSO, L-tyrosine, MSH analogs).
  • Comparison of efficacy and safety across various models (cells, animal, human skin).

Main Results:

  • Dihydroxyacetone and topical melanins offer some photoprotection and are consumer-available.

Related Experiment Videos

  • PUVA and MSH analogs show human efficacy but raise safety concerns.
  • Several agents under development show potential for safe, photoprotective tanning.

    • Conclusions:

    • Topical melanins and dihydroxyacetone provide a degree of photoprotection.
    • Stimulators like PUVA and MSH analogs have safety issues.
    • Emerging agents may offer safe tanning and photoprotection.