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Rhabdomyolysis, acute renal failure, and death after monensin ingestion

C Caldeira1, W S Neves, P M Cury

  • 1Division of Nephrology, Intensive Care Unit, Service of Toxicology, and Department of Pathology, Hospital de Base, São José do Rio Preto Medical School, São José do Rio Preto, SP, Brazil.

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|October 31, 2001
PubMed

Insights

This is the first reported human case of monensin intoxication, mimicking veterinary poisoning. High doses caused severe rhabdomyolysis, organ failure, and death, highlighting monensin toxicity risks.

Area of Science:

  • Toxicology
  • Human Pathology
  • Veterinary Medicine

Background:

  • Monensin is an ionophore antibiotic used in veterinary medicine.
  • Human monensin intoxication is not previously documented in medical literature.

Observation:

  • A patient ingested a monensin dose significantly exceeding the lethal dose for cattle.
  • The patient presented with severe rhabdomyolysis, acute renal failure, and heart failure.

Findings:

  • Autopsy revealed extensive skeletal muscle necrosis and acute tubular damage.
  • Myocardial complement deposition and pulmonary edema were also observed.

Implications:

  • This case establishes a precedent for human monensin toxicity.
  • It underscores the potential dangers of monensin overdose and the need for caution.

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