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A Src-astic response to mounting tension.

D G Jay1

  • 1Department of Physiology, Tufts University School of Medicine, Boston, MA 02111, USA. djay01@emerald.tufts.edu

The Journal of Cell Biology
|October 31, 2001
PubMed
Summary
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Nerve growth cones use guidance cues to direct axon growth. A study reveals how Src family tyrosine kinase strengthens connections to extracellular cues, potentially amplifying guidance signals through a positive feedback loop.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Molecular Biology

Background:

  • Nerve growth cones navigate complex environments using guidance cues.
  • Axon outgrowth direction is controlled by cytoskeletal interactions influenced by these cues.
  • Signal transduction pathways are crucial for interpreting guidance information.

Discussion:

  • Suter and Forscher (2001) investigate the role of Src family tyrosine kinase in growth cone guidance.
  • This kinase enhances cytoskeletal linkage to apCAM, a key extracellular cue for Aplysia growth cones.
  • Applied tension increases localized phosphorylation of the kinase, strengthening the linkage.

Key Insights:

  • Src family tyrosine kinase activity is modulated by mechanical tension.
  • Phosphorylation of the kinase by tension strengthens its interaction with apCAM.

Related Experiment Videos

  • This mechanism suggests a positive feedback loop for amplifying guidance signals.

    • Outlook:

    • Understanding this feedback mechanism can elucidate growth cone motility and axon pathfinding.
    • Further research may reveal therapeutic targets for neurological disorders involving axon guidance defects.
    • This study provides a foundation for exploring mechanotransduction in neuronal development.