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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
Mantle cell lymphoma presenting as a breast mass
P Windrum1, T C Morris, M A Catherwood
1Department of Haematology, Belfast City Hospital, Lisburn Road, Belfast BT9 7AD, Northern Ireland, UK.
Journal of Clinical Pathology
|October 31, 2001
Summary
This case study describes a rare instance of mantle cell lymphoma (MCL) presenting as a breast lump. Early detection through specialized investigations is crucial for this specific non-Hodgkin's lymphoma (NHL).
Area of Science:
- Oncology
- Hematology
- Pathology
Background:
- Breast lymphoma is a rare malignancy, comprising less than 1% of non-Hodgkin's lymphomas (NHLs) and approximately 0.1% of all breast neoplasms.
- Common types include diffuse large B-cell lymphoma and mucosa-associated lymphoid tissue (MALT) lymphoma.
Observation:
- A 53-year-old woman presented with a breast mass.
- Initial core biopsy indicated a high-grade B-cell NHL, possibly large cell type.
- Further analysis suggested mantle cell lymphoma (MCL).
Findings:
- Morphological and immunophenotypic analysis of peripheral blood and bone marrow supported an MCL diagnosis.
- Genetic confirmation of t(11;14) translocation was achieved via polymerase chain reaction in bone marrow and breast tissue.
- This represents the first reported case of MCL presenting solely as a breast lump.
Implications:
- Mantle cell lymphoma diagnosis has significant prognostic and therapeutic implications.
- Highlights the importance of considering MCL in breast masses, even when rare.
- Emphasizes the necessity of specialized investigations for accurate MCL detection.
