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Hepatitis C-associated peripheral corneal ulceration: rapid response to intravenous steroids
1Washington National Eye Center, Washington Hospital Center, Department of Ophthalmology, Washington, DC, USA. pluznik@hotmail.com
Purpose:
We present a case of peripheral corneal ulceration in a patient with hepatitis C, which rapidly and dramatically responded to intravenous steroid treatment.
Methods:
Clinical examination and photographs were obtained to document initial presentation and therapeutic response of Mooren's-type ulcers to steroids.
Results:
Bilateral peripheral corneal ulceration with documented progression responded to intravenous administration of steroids within 5 days.
Conclusion:
Previous reports of Mooren's-type ulcers in patients with chronic hepatitis C have shown a response to interferon alfa-2b, but not to oral corticosteroid therapy. Given the medical contraindications to interferon use in selected patients and the cost, we suggest a trial of high-dose systemic steroids as a possible therapy.
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