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Updated: Aug 11, 2026

Real-time X-ray Imaging of Lung Fluid Volumes in Neonatal Mouse Lung
Published on: July 18, 2016
High-resolution CT of the lungs in infants and young children
1Columbus Children's Hospital, Ohio State University, Columbus, OH 43205, USA. flong@chi.osu.edu
Abstract:
The effects of respiratory motion and imaging at low tidal volumes can easily obscure normal anatomy as well as pathology on high-resolution computed tomography (HRCT) images of the lungs in infants and young children. The benefits of motion-free HRCT in children at full inflation and end exhalation compared with HRCT during quiet breathing has remained largely unexplored. The authors describe the application and benefits of a physiologic, noninvasive technique called controlled-ventilation to obtain high-quality HRCT images of the lungs, similar to those obtained in adults, in uncooperative young children. The availability of this method should result in greater application of HRCT as a clinical and research tool in the evaluation of childhood respiratory disease.
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