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Intracranial haemorrhage within the first two years of life
D C Suh1, H Alvarez, J J Bhattacharya
1Department of Radiology, Asan Medical Center, University of Ulsan, College of Medicine, Seoul Korea.
Insights
Spontaneous intracranial hemorrhage in infants is rare and linked to specific vascular lesions. Vein-related causes are common, with some hemorrhages occurring after shunting procedures.
Area of Science:
- Pediatric Neurology
- Vascular Malformations
- Neuroimaging
Background:
- Spontaneous intracranial hemorrhage (SIH) is uncommon in infants, differing in cause and severity from adults.
- Infantile central nervous system (CNS) vulnerability is heightened due to immature hydrovenous development.
- Analysis focuses on SIH in infants primarily caused by structural brain lesions and their hemodynamic characteristics.
Purpose of the Study:
- To analyze the specific etiologies of spontaneous intracranial hemorrhage in infants.
- To investigate the hemodynamic characteristics associated with infantile intracranial hemorrhage.
- To compare infantile intracranial hemorrhage with adult counterparts.
Main Methods:
- Retrospective review of 20 infants under 2 years with intracranial vascular lesions.
- Identification of associated lesions including arteriovenous malformation (AVM), dural sinus malformation (DSM), arteriovenous fistula (AVF), aneurysm, developmental venous anomaly (DVA), and vein of Galen malformation (VGAM).
- Categorization of hemorrhage locations: intracerebral (ICH), intraventricular (IVH), subarachnoid (SAH), and subdural (SDH).
Main Results:
- Three hemorrhage patterns observed in high-flow lesions (AVM/AVF): nidal pseudoaneurysm, regional venous hypertension, and global venous infarction.
- Aneurysmal bleeds originated from dissecting aneurysms near cranial vessel dural penetration.
- Intraventricular hemorrhage (IVH) was linked to shunt operations in DSM cases; subdural hemorrhage (SDH) followed by ICH occurred in a VGAM case.
Conclusions:
- Infantile SIH is rare, associated with distinct lesions differing from adult presentations.
- Vein-related pathologies are significant contributors to hemorrhage in this age group.
- Absence of hemorrhage in vein of Galen malformation (VGAM) and post-shunting hemorrhages are notable findings.
Background:
Spontaneous intracranial haemorrhage is not common in infants, with differences from adults in both aetiology and severity. The infantile CNS is more vulnerable because of incomplete hydrovenous maturation. We analyzed infantile intracranial haemorrhage mainly caused by structural brain lesions and discuss specific aetiologies with regard to haemodynamic characteristics.
Subjects And Methods:
We reviewed 20 infants less than 2 years of age from a total of 328 neonates and infants with intracranial vascular lesions seen in our institution since 1985. Associated or causative lesions were arteriovenous malformation (AVM) in 6, dural sinus malformation (DSM) in 4, arteriovenous fistula (AVF) in 3, aneurysm in 2, developmental venous anomaly (DVA) in 1, vein of Galen malformation (VGAM) in 1, and others in 3. The locations of haematomas were intracerebral (ICH) in 8, combined ICH and intraventricular haemorrhage (IVH) in 5, IVH alone in 5, subarachnoid haemorrhage (SAH) in 1, and combined SDH and ICH in 1.
Findings:
Three patterns of haemorrhage were noted in high-flow vascular lesions such as AVM or AVF (n=9); haemorrhage at the site of nidus or fistula corresponding to nidal pseudoaneurysm in 4, regional venous hypertension with pial venous reflux in 3, global venous infarction causing multifocal haemorrhage in distant brain areas in 2. Aneurysmal bleeds were caused by dissecting aneurysms at the level of dural penetration of cranial vessels. One infant had haemorrhage near a DVA without evidence of cavernous malformation suggesting the possibility of venous ischaemia. IVH was associated with shunt operations in 4 infants with DSM, and SDH followed by ICH in a infant with VGAM.
Interpretation:
Spontaneous intracranial haemorrhage in infants and neonates is rare; it is associated with specific lesions which show some differences from their adult counterparts. The vein-related causes of hemorrhage are largely the pathophysiologic characteristics in this age group. Absence of hemorrhage in VGAM is remarkable in addition to occurrence of most hemorrhages after shunting.