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The role of high-density lipoproteins in oxidation and inflammation

B J Van Lenten1, M Navab, D Shih

  • 1Department of Medicine, University of California, Los Angeles, California, USA. bvanlent@mednet.ucla.edu

Trends in Cardiovascular Medicine
|November 1, 2001
PubMed

Insights

High-density lipoproteins (HDL) are anti-inflammatory normally but become pro-inflammatory during acute inflammation due to their complex composition. This dynamic nature of HDL significantly impacts inflammation and the development of atherosclerosis.

Area of Science:

  • Cardiovascular science
  • Lipid metabolism
  • Immunology

Background:

  • High-density lipoproteins (HDL) possess anti-inflammatory properties in their basal state.
  • HDL can neutralize oxidized lipids, preventing inflammatory responses.
  • HDL's composition is complex, leading to functional alterations.

Purpose of the Study:

  • To review the dual role of HDL in inflammation.
  • To explore the implications of HDL's inflammatory modulation in atherogenesis.

Main Methods:

  • Literature review of studies investigating HDL function.
  • Analysis of HDL composition and its correlation with inflammatory states.
  • Examination of HDL's role in the context of atherosclerosis.

Main Results:

  • HDL exhibits a "chameleon-like" behavior, shifting from anti-inflammatory to pro-inflammatory.
  • Acute inflammation alters HDL, promoting inflammatory processes.
  • HDL's composition is critical to its functional plasticity.

Conclusions:

  • HDL plays a pivotal role in modulating inflammatory responses.
  • The dynamic nature of HDL has significant implications for the pathogenesis of atherosclerosis.

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