Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Analytical models for time resolved fluorescence spectroscopy in tissues.

M Sadoqi1, P Riseborough, S Kumar

  • 1Department of Physics, St John's University, Jamaica, NY 11439, USA.

Physics in Medicine and Biology
|November 1, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tuning the magnetoresistance properties of phosphorene with periodic magnetic modulation.

Journal of physics. Condensed matter : an Institute of Physics journal·2023
Same author

Active brain targeting of a fluorescent P-gp substrate using polymeric magnetic nanocarrier system.

Nanotechnology·2012
Same author

The formulation, characterization and in vivo evaluation of a magnetic carrier for brain delivery of NIR dye.

Nanotechnology·2010
Same author

Transition from heavy-fermion to mixed-valence behavior in Ce(1-x)Y(x)Al3: a quantitative comparison with the anderson impurity model.

Physical review letters·2010
Same author

Investigation of the micellar properties of the tocopheryl polyethylene glycol succinate surfactants TPGS 400 and TPGS 1000 by steady state fluorometry.

Journal of colloid and interface science·2009
Same author

Observation of a continuous phase transition in a shape-memory alloy.

Physical review letters·2008

This study models fluorescence signals in scattering materials using coupled photon migration. It analyzes fluorescence lifetimes, advancing in vivo biomedical diagnostics beyond steady-state spectrum measurements.

Area of Science:

  • Biomedical Optics
  • Photonics
  • Biophysical Imaging

Background:

  • Laser-induced fluorescence (LIF) is crucial for in vivo biomedical diagnostics and imaging in scattering tissues.
  • Traditional LIF analysis relies on steady-state emission spectra, limiting diagnostic capabilities.
  • Emerging research explores fluorescence lifetimes, influenced by light scattering, for enhanced diagnostic potential.

Purpose of the Study:

  • To develop a comprehensive model for analyzing fluorescence signals in scattering media.
  • To investigate the coupled photon migration phenomena of excitation and emission light.
  • To provide analytical and numerical solutions for diverse geometrical configurations.

Main Methods:

  • Developed a model simulating fluorescence signal generation in scattering media.

Related Experiment Videos

  • Incorporated coupled time-dependent photon migration for pulsed laser excitation and induced fluorescence.
  • Accounted for local fluorescence emission strength based on absorbed laser intensity.

    • Main Results:

    • Presented general analytical and numerical solutions for fluorescence signal modeling.
    • Demonstrated the capability to analyze fluorescence in various geometries (finite, infinite, cylindrical, spherical).
    • Provided a framework for understanding transport phenomena in LIF diagnostics.

    Conclusions:

    • The developed model advances the use of fluorescence lifetimes for in vivo biomedical diagnostics.
    • This approach offers a more robust method compared to traditional steady-state spectral analysis.
    • The study provides essential tools for researchers investigating light-tissue interactions and optical imaging.