Related Experiment Video
Updated: Aug 6, 2026

Pressure Controlled Ventilation to Induce Acute Lung Injury in Mice
Published on: May 5, 2011
Pressure-controlled ventilation via a minitracheostomy tube: experimental study using a mechanical lung model
1Department of Thoracic Surgery, Saiseikai Central Hospital, Tokyo, Japan.
Pressure-controlled ventilation (PCV) via a minitracheostomy tube (MTT) can provide adequate airflow, even with air leaks. However, low lung compliance significantly reduces ventilation effectiveness, requiring higher inspiratory pressures.
Area of Science:
- Mechanical Ventilation
- Respiratory Physiology
Background:
- Minitracheostomy tubes (MTTs) are used for airway management.
- Pressure-controlled ventilation (PCV) is a common ventilation mode.
Purpose of the Study:
- To evaluate the efficacy of PCV delivered through MTTs.
- To assess the impact of MTT diameter and lung compliance on ventilation.
Main Methods:
- Experimental study using a mechanical lung model.
- Tested MTTs with internal diameters of 4.0, 4.5, and 5.0 mm.
- Measured ventilated volumes and alveolar pressures at varying lung compliances (10-50 ml/cmH2O).
Main Results:
- Ventilated volumes and alveolar pressures were reduced with smaller MTTs compared to an 8.0-mm endotracheal tube.
- Air leakage further decreased ventilation by approximately 20%.
- Lower lung compliance (10 ml/cmH2O) resulted in a 60% reduction in ventilated volumes compared to normal compliance (50 ml/cmH2O).
- Higher inspiratory pressures were required to achieve target volumes with smaller MTTs.
Conclusions:
- PCV via MTT can achieve acceptable ventilation in models with air leakage.
- Low lung compliance poses a significant challenge, necessitating higher inspiratory pressures for effective ventilation with MTTs.
Related Concept Videos
Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen
Venturi Mask
The Venturi mask, named after the Venturi effect, is designed to deliver precise oxygen concentrations. It consists of a large tube with an oxygen inlet that narrows down, causing a pressure drop that pulls air in through adjustable side ports. The mask is a lightweight,...
Tracheostomy Decannulation
Description of the Procedure
Decannulation refers to the permanent removal of the tracheostomy tube, signaling the resolution of the condition that initially necessitated the tracheostomy. The process requires a well-coordinated interplay between...
Mechanical Ventilation I: Indication and Settings
Mechanical Ventilation II: Invasive Ventilation
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
Mechanical Ventilation III: Noninvasive Ventilation
Noninvasive Positive-Pressure Ventilation (NIPPV)
Ventilatory Modes
There are three ventilatory modes: full support, partial support, and spontaneous. These are described below.
Full Support Modes
Full support modes include controlled mechanical ventilation, continuous mandatory...

